Publications

Löffler M, Levine SM, Usai K, Desch S, Kandić M, Nees F, Flor H. Corticostriatal circuits in the transition to chronic back pain: The predictive role of reward learning. Cell Rep Med. 3:100677, 2022.

Nees F, Ditzen B, Flor H. When shared pain is not half the pain: enhanced central nervous system processing and verbal reports of pain in the presence of a solicitous spouse. Pain. 163:e1006-e1012, 2022.

Tesarz J, Nees F. Pain, the brain, and SARS-CoV-2: evidence for pain-specific alterations in brain-related structure–function properties. Neuroforum. 28:105-116, 2022.

Kandic M, Moliadze V, Andoh J, Flor H, Nees F. Reward vs non-reward sensitivity of the medial vs lateral orbitofrontal cortex relates to the severity of depressive symptoms Front. Neurol. 2021 Aug 31;12:732034. doi: 10.3389/fneur.2021.732034.

Xie, C., Jia, T., Rolls, E.T., Robbins, T.W., Sahakian, B.J., Zhang, J., Liu, Z., Cheng, W., Luo, Q., Zac Lo, C.-Y., Wang, H., Banaschewski, T., Barker, G.J., Bokde, A.L:W., Büchel, C., Quinlan, E.B., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Hohmann, S., Ittermann, B., Martinot, J.-L., Paillère-Martinot, M.L., Nees, F., Orfanos, D.P., Paus, T., Poustka, L., Fröhner, J.H., Smolka, M.N., Walter, H., Whelan, R., Schumann, G., Feng, Y., & the IMAGEN Consortium (2021).  Reward vs non-reward sensitivity of the medial vs lateral orbitofrontal cortex relates to the severity of depressive symptoms. Biological Psychiatry Cognitive Neurosience and Neuroimaging, 2021 Mar;6(3):259-269.

Nees F, Ruttorf M, Fuchs X, Rance M, Beyer N. (2020). Brain-behaviour correlates of habitual motivation in chronic back pain. Scientific Reports, 10(1), 11090. doi: 10.1038/s41598-020-67386-8.

Nees F, Ruttorf M, Fuchs X, Rance M, Beyer N. Volumetric brain correlates of approach-avoidance behavior and their relation to chronic back pain. Brain Imaging Behav. 2020 Oct; 14(5):1758-1768. doi: 10.1007/s11682-019-00110-x.PMID: 31065925

Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, Keefe FJ, Mogil JS, Ringkamp M, Sluka KA, Song XJ, Stevens B, Sullivan MD, Tutelman PR, Ushida T, Vader K. (2020). The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 161:1976-1982.

Boll S, Ueltzhoeffer K, Roth C, Bertsch K, Desch S, Nees F, Grinevich V, Herpertz SC. Pain-modulating effects of oxytocin in patients with chronic low back pain. Neuropharmacology. 2020 Jul;171:108105. doi: 10.1016/j.neuropharm.2020.108105. Epub 2020 Apr 13.PMID: 32298704 Clinical Trial. (project-related, with B02)

Schneider I, Schmitgen MM, Boll S, Roth C, Nees F, Usai K, Herpertz SC, Wolf RC . Oxytocin modulates intrinsic neural activity in patients with chronic low back pain. Eur J Pain. 2020 May;24(5):945-955. doi: 10.1002/ejp.1543. Epub 2020 Mar 9.PMID: 32061140 (project-related, with B02)

Herpertz SC, Schmitgen MM, Fuchs C, Roth C, Wolf RC, Bertsch K, Flor H, Grinevich V, Boll S (2019). Oxytocin Effects on Pain Perception and Pain Anticipation. J Pain. 2019 Oct; 20(10):1187-1198. (project-related, with B02)

Schmitz J, Müller M, Stork J, Eichler I, Zöllner C, Flor H, Klinger R. Positive Treatment Expectancies Reduce Clinical Pain and Perceived Limitations in Movement Ability Despite Increased Experimental Pain: A Randomized Controlled Trial on Sham Opioid Infusion in Patients with Chronic Back Pain. Psychother Psychosom. 2019;88(4):203-214. doi: 10.1159/000501385. Epub 2019 Jul 12. PMID: 31302644 Clinical Trial.

Finnern M, Kleinböhl D, Flor H, Benrath, J & Hölzl R (in press). Differential sensory and clinical phenotypes of patients with chronic widespread and regional musculoskeletal pain. Pain.

Qi, S., Schumann, G., Bustillo, J., Turner, J. A., Jiang, R., Zhi, D., Fu, Z., Mayer, A. R., Vergara, V. M., Silva, R. F., Iraji, A., Chen, J., Damaraju, E., Ma, X., Yang, X., Stevens, M., Mathalon, D. H., Ford, J. M., Voyvodic, J., Mueller, B. A.,Belger, A., Potkin, S.G., Preda, A., Zhuo, C., Xu, Y., Chu, C., Banaschewski, T., Barker, G.J.,  Bokde, A.L.W., Quinlan, E.B:, Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Martinot, J.-L., Paillière-martinot, M.-L., Artiges, E., NBees, F., Orfanos, D.P., Paus, T., Poustka, L., Hohmann, S., Fröhner, J.H., Smolka, M.N., Walter, H., Whelan, R., Calhoun, V., Sui, J., and the IMAGEN Consortium (in press). Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker. Biological Psychiatry.

Becker, S., Navratilova, E., Nees, F. & Van Damme, S. (2018). Emotional and motivational pain processing: Current state of knowledge and perspectives in translational research. Pain Research & Management, 2018, No. 5457870.

MA, Winkelmann T, Pohlack S, Cavalli J, Nees F, Flor H. (2019). Memory-guided attention: bilateral hippocampal volume positively predicts implicit contextual learning. Brain Struct Funct. 224(6):1999-2008.

Cao, Z., Bennett, M., Orr, C., Icke, I., Banaschewski, T., Barker, G., Bokde, A., Bromberg, U., Büchel, C., Quinlan, E., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Nees, F., Orfanos, D. P., Paus, T., Poustka, L., Hohmann, S., Fröhner, J.H., Smolka, M., Walter, H., Schumann, G., Whelan, R., & the IMAGEN Consortium (2019). Mapping adolescent reward anticipation, receipt and prediction error during the Monetary Incentive Delay task. Human Brain Mapping, 40, 262-283.

Galinowski, A., Miranda, R., Lemaitre, H., Artiges, E., Paillière Martinot, M. L., Filippi, I., Penttilä, J., Grimmer, Y., van Noort, B.M., Stringaris, A., Becker, A., Isensee, C., Struve, M., Fadai, T., Kappel, V., Goodman, R, Banaschewski, T., Bokde, A.L.W., Bromberg, U., Brühl, R., Büchel, C., Cattrell, A., Conrod, P., Desrivères, S., Flor, H., Fröhner, J.H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Hohmann, S., Jurk, S. Millenet, S., Nees, F., Papadopoulos-Orfanos, D., Poustka, L., Quinlan, E.B., Smolka, M.N., Walter, H., Whelan, R., Schumann, G., Martinot, J.L., & the IMAGEN Consortium (2019). Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity. Addiction Biology,e12781.

Nees F, Löffler M, Usai K, Flor H. Hypothalamic-pituitary-adrenal axis feedback sensitivity in different states of back pain. Psychoneuroendocrinology 2019; 101:60-6. (B03 project-specific)

Nees F, Usai K, Löffler M, Flor H. The evaluation and brain representation of pleasant touch in chronic and subacute back pain. Neurobiology of Pain 2019; 5:100025.(B03 project-specific)

Finnern MM, Kleinböhl D, Flor H, Benrath J, Hölzl R. Scand J Pain. Deconstructing chronicity of musculoskeletal pain: intensity-duration relations, minimal dimensions and clusters of chronicity. 2018 Jul 26;18(3):363-377. doi: 10.1515/sjpain-2018-0021. PMID: 29870396

Becker S, Navratilova E, Nees F, Van Damme S.Pain Res Manag. Shared Mechanisms of Chronic Pain and Emotional-Motivational Problems: From Basic Science to the Clinics.2018 Nov 19; 2018:9305026. doi: 10.1155/2018/9305026. eCollection 2018.PMID: 30581516 Free PMC article. No abstract available.

Nees F, Becker S. Psychological Processes in Chronic Pain: Influences of Reward and Fear Learning as Key Mechanisms – Behavioral Evidence, Neural Circuits, and Maladaptive Changes. Neuroscience. 2018 Sep 1;387:72-84. doi: 10.1016/j.neuroscience.2017.08.051. Epub 2017 Sep 7.PMID: 28890049 Review. (project-specific, special issue SFB1158)

Nees F, Becker S, Millenet S, Banaschewski T, Poustka L, Bokde AU, Bromberg U, BüchelC, Conrod PJ, Desrivières S, Frouin V, Gallinat J, Garavan H, Heinz A, Ittermann B, Martinot J-L, Papadopoulos-Orfanos D, Paus T, Smolka M, Walter H, Whelan R, Schumann G, Flor H, the IMAGEN consortium. Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain? Pain2017;158:212-9. (project-related)

Lonsdorf TB, Menz MM, Andreatta M, Fullana MA, Golkar A, Haaker J, Heitland I, Hermann A, Kuhn M, Kruse O, Meir Drexler S, Meulders A, Nees F, Pittig A, Richter J, Römer S, Shiban Y, Schmitz A, Straube B, Vervliet B, Wendt J, Baas JMP, Merz CJ. (2017).

van Dieën JH, Flor H, Hodges PW (2017). Low-Back Pain Patients Learn to Adapt Motor Behavior With Adverse Secondary Consequences. Exerc Sport Sci Rev. 45(4):223-229.

Schiltenwolf M, Akbar M, Neubauer E, Gantz S, Flor H, Hug A, Wang H. Scand J Pain. The cognitive impact of chronic low back pain: Positive effect of multidisciplinary pain therapy. 2017 Oct;17:273-278. doi: 10.1016/j.sjpain.2017.07.019. Epub 2017 Oct 7. PMID: 28993113

Davis KD, Flor H, Greely HAT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD. Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. Nat Rev Neurosci 2017; 13:624-38. (project-related)

Flor H. Pain has an element of blank-a biobehavioral approach to chronicity.Pain2017;158:S92-S96. (project-related)

Klinger R, Kothe R, Schmitz J, Kamping S, Flor H. Placebo effects of a sham opioid solution: a randomized controlled study in patients with chronic low back pain. Pain 2017; 158:1893-1902. (project-related)

Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R,Kuner T,& Kuner R. A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nature Neuroscience 2017; 20:1591-1601. (B03 project-related, with R.Kuner, ↔B01; T. Kuner, ↔B08; Gangadharan,↔A03; Sprengel, ↔A05)

Kuner R, Flor H. Structural plasticity and reorganisation in chronic pain. Nat Rev Neurosci 2016;18:20-30. (B03 project-specific, with Kuner, ↔ B01)

Flor H. Psychological pain interventions and neurophysiology: implications for a mechanism-based approach.Am Psychol 2014; 69:188-96. (project-related)

Rance M, Ruttorf M, Nees F, Schad LR, Flor H. Real-time fMRI feedback of the anterior cingulate and posterior insula cortex in the processing of pain. Hum Brain Mapp 2014;35:5784-98. (project-related)