Publications
 
Damo E, Agarwal A, Simonetti M. Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice. Cells 2023, 12(2), 284; https://doi.org/10.3390/cells12020284.

Damo E, Rieder P, Coban I, Silva RL, Kirchhoff F, Simonetti M, Agarwal A. Glial cells as target for antidepressants in neuropathic pain. Neuroforum. 28:85-94, 2022. https://doi.org/10.1515/nf-2021-0036.

Damo E, Simonetti M. Axon guidance molecules and pain. Cells 2022 Oct 6;11(19):3143. doi: 10.3390/cells11193143.

Rieder P, Gobbo D, Stopper G, Welle A, Damo E, Kirchhoff F, Scheller A. Astrocytes and microglia exhibit cell-specific Ca(2+) signalling dynamics in the murine spinal cord. Front Mol Neurosci. 2022 Mar 30;15:840948.  doi: 10.3389/fnmol.2022.840948. eCollection 2022

Simonetti M, Kuner R. Locus revealed: Painlessness via loss of NaV1.7 at central terminals of sensory neurons. Neuron 2021 May 5;109(9):1413-1416. doi:10.1016/j.neuron.2021.04.011. PMID: 33957067.

Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R. The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Mol Psychiatry. 2021 Apr;26(4):1376-1398. doi: 10.1038/s41380-019-0491-4. Epub 2019 Aug 23. PMID: 31444474; PMCID: PMC7985029.
 
Streich L., Boffi J., Wang L., Alhalaseh K., Barbieri M., Rehm R., Deivasigamani S., Gross C., Agarwal A., Prevedel R. (2021) High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy bioRxiv 2021.01.12.426323 (Nature Methods, in Press).
 
Escartin C., Galea E., Lakatos A., O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Zorec R, Sofroniew MV, Verkhratsky A et al.,. (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience Mar;24(3):312-325.

Simonetti M , Kuner R. Spinal Wnt5a plays a key role in spinal dendritic spine remodeling in neuropathic and inflammatory pain models and in the pro-algesic effects of peripheral Wnt3a. J Neurosci. 2020 Aug 26;40(35):6664-6677. doi: 10.1523/JNEUROSCI.2942-19.2020.

Hirth M, Gandla J, Höper C, Gaida MM, Agarwal N, Simonetti M, Demir A, Xie Y, Weiss C, Michalski CW, Hackert T, Ebert MP, Kuner R. CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients. Gastroenterology. 2020 Aug;159(2):665-681.e13. doi: 10.1053/j.gastro.2020.04.037. Epub 2020 Apr 21. PMID: 32330476.
 
Ye L., Orynbayev M., Zhu X., Lim E.Y., Dereddi R.R., Agarwal A., Bergles D.E., Bhat M.A., Paukert M. (2020) Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release. Nature Communications Dec 2;11(1):6157
 
Semyanov A., Henneberger C., and Agarwal A. (2020) Making sense of astrocytic calcium signals — from acquisition to interpretation. Nature Reviews Neuroscience Oct;21(10):551-564.
 
Faust, T.E, Xin, W., Lee, B., Agarwal, A., Saha, S., Palen, T., Cash-Padgett, T., Wood, D., Bonci, A., Fahey, J.W., Jaaro-Peled, H., Bergles, D.E., Sawa, A. (2019) Astrocyte redox dysregulation causes prefrontal hypoactivity: sulforaphane treats non-ictal pathophysiology in ALDH7A1-mediated epilepsy. bioRxiv 796474; doi: https://doi.org/10.1101/796474
 
Cartarozzi LP, Rieder P, Bai X, Scheller A, Oliveira ALR, Kirchhoff F. In vivo two-photon imaging of motoneurons and adjacent glia in the ventral spinal cord. J. Neuroscience Methods 2018, 299:8-15.

Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 2017 Feb 8;93(3):587-605.

Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron 2016 Sep 7;91(5):1085-1096

Perea G, Gómez R, Mederos S, Covelo A, Ballesteros JJ, Schlosser L, Hernández-Vivanco A, Martín-Fernández M, Quintana R, Rayan A, Díez A, Fuenzalida M, Agarwal A, Bergles DE, Bettler B, Manahan-Vaughan D, Martín ED, Kirchhoff F, Araque A. Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks. Elife 2016 Dec 24;5

Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nature Medicine 2015 May;21(5):518-23. 

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R. Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways. Neuron 2014 Jul 2;83(1):104-21

Paukert M, Agarwal A, Cha J, Doze VA, Kang JU, Bergles DE. Norepinephrine controls astroglial responsiveness to local circuit activity. Neuron 2014 Jun 18;82(6):1263-70

Simonetti M, Hagenston AM, Vardeh D, Freitag HE, Mauceri D, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R. Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain. Neuron 2013 Jan 9;77(1):43-57. 

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F. Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine 2012, 18:166-71.

Dibaj P, Nadrigny F, Steffens H, Scheller A, Hirrlinger J, Schomburg ED, Neusch C, Kirchhoff F. NO mediates microglial response to acute spinal cord injury under ATP control in vivo. Glia 2010, 58:1133-44.

 

News

  • New collaborative research results

    Published in Science

     

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  • ERC Synergy Grant 2022

    Congratulations to Prof. Dr. Valery Grinevich!

     

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  • John J. Bonica Prize of the IASP

    Congratulations to Prof. Dr. Rolf Detlef-Treede!

     

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  • New paper published in Nature

    Collaboration involving Projects A01, A03, B01, B06 and B08.

     

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  • Pain Summer School

    "Chronic Pain and its affective consequences"

     

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