Jun.-Prof. Dr. Daniela Mauceri

Department of Neurobiology, Bioscience Faculty, Heidelberg University

Prof. Dr. Carmen Ruiz-de-Almodovar

European Center for Angioscience, Institute for Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University

 

Pain-associated epigenetic alterations and spinal sensitization: role of the neurovascular unit
 

Long-lasting alterations of epigenetic processes in dorsal horn are causally linked to sensitization in chronic pain. How these long-lasting changes are modulated is still not defined. Alterations in the neurovascular unit (NVU) have not been thoroughly investigated in the context of chronic pain. Moreover, how the NVU might impact neuronal epigenetic processes, thereby sustaining maladaptive changes, is also elusive.
 
Key Questions:
  1. 1. Is the NVU in the spinal cord altered in chronic pain?
  2. 2. Which NVU related factors are affecting epigenetic changes in spinal cord dorsal horn neurons?
  3. 3.Do alterations of the NVU functionality contribute to epigenetic changes and to the establishment and maintenance of hypersensitivity?”

     

News

  • ECNP Neuropsychopharmacology Award

    Congratulations to Prof. Dr. Valery Grinevich (Project B02)!

     

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  • Silvia King Award 2021

    Congratulations to Dr. Johann Jende (Project A03)!

     

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  • SFB1158 and NIKON BioImage Analysis Workshop

    Registration deadline extended until 30 April 2021

     

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  • Latest research from Project B02

    (New paper published in Nature Neuroscience)

     

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  • Webinar, "Multiomics Single Cell Analysis and Spatial Gene Expression Analysis of Intact Tissues"

    Register now for this webinar on February 17, 2021

     

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