Schrenk-Siemens K, Pohle J, Rostock C, Abd El Hay M, Lam RM, Szczot M, Lu S, Chesler AT, Siemens J. Human stem cell-derived TRPV1-positive sensory neurons: A new tool to study mechanisms of sensitization. Cells. 11, 2022 Sep 17;11(18):2905. doi: 10.3390/cells11182905.

Yan, J., Bengtson, C.P., Buchthal, B., Hagenston, A.M., Bading, H. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science 2020 Oct 9;370(6513):eaay3302. doi: 10.1126/science.aay3302.

Mauceri D, Buchthal B, Hemstedt TJ, Weiss U, Klein CD, Bading H. Nasally delivered VEGFD mimetics mitigate strokeinduced dendrite loss and brain damage. Proc Natl Acad Sci USA. 2020 Apr 14;117(15):8616-8623. doi: 10.1073/pnas.2001563117. Epub 2020 Mar 30.

Litke C, Bading HMauceri D. Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D. J Biol Chem 2018;293(21):8196-8207.

Chandrasekar A, Olde Heuvel F, Tar L, Hagenston AM, Palmer A, Linkus B, Ludolph AC, Huber-Lang M, Boeckers T, Bading H, Roselli F. Parvalbumin Interneurons Shape Neuronal Vulnerability in Blunt TBI. Cereb Cortex 2018.

Rostock C, Schrenk-Siemens K, Pohle J, Siemens J. Human vs. Mouse Nociceptors - Similarities and Differences. Neu-roscience 2018;387:13-27.

Bas-Orth C, Tan YW, Lau D, Bading H. Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect. J Biol Chem 2017;292(13):5183-5194.

Song K, Wang H, Kamm GB, Pohle J, Reis FC, Heppenstall P, Wende H, Siemens J. The TRPM2 channel is a hypotha-lamic heat sensor that limits fever and can drive hypothermia. Science 2016;353(6306):1393-1398.

Schrenk-Siemens K, Wende H, Prato V, Song K, Rostock C, Loewer A, Utikal J, Lewin GR, Lechner SG, Siemens J.PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Nat Neurosci. 2015 Jan;18(1):10-6. doi: 10.1038/nn.3894. Epub 2014 Dec 3.

Mauceri D, Hagenston AM, Schramm K, Weiss U, Bading H. Nuclear Calcium Buffering Capacity Shapes Neuronal Ar-chitecture. J Biol Chem 2015;290(38):23039-23049.

Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens KTappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J. GABA blocks pathological but not acute TRPV1 pain signals. Cell 2015;160(4):759-770.

Hagenston AM, Simonetti M. Neuronal calcium signaling in chronic pain. Cell Tissue Res 2014;357(2):407-426.

Simonetti M, Hagenston AM, Vardeh D, Freitag HE, Mauceri D, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R. Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflam-matory pain. Neuron 2013;77(1):43-57.


Other publications:

Marty-Lombardi S, Lu S, Ambroziak W, Wende H, Schrenk-Siemens K, DePaoli-Roach AA, Hagenston AM, Tappe-Theodor A, Simonetti M, Kuner R, Fleming T, Siemens J. Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain. bioRxiv.2022.2012.2003.518519, 2022,
DOI:, also under revision at Nature Metabolism.



  • New collaborative research results

    Published in Science


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  • ERC Synergy Grant 2022

    Congratulations to Prof. Dr. Valery Grinevich!


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  • John J. Bonica Prize of the IASP

    Congratulations to Prof. Dr. Rolf Detlef-Treede!


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  • New paper published in Nature

    Collaboration involving Projects A01, A03, B01, B06 and B08.


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  • Pain Summer School

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