SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganization
What underlies the ‘Dr. Jekyll and Mr. Hyde’ nature of this key physiological function that has protected the animal kingdom from harm throughout evolution?
Why does pain convert into a disorder by becoming chronic?
And importantly, can we prevent, treat or revert these changes?
These questions are at the heart of the new Heidelberg Pain Consortium. Established by the German Research Foundation at Heidelberg University in July 2015, this centre comprises nineteen multidisciplinary projects and several associated research endeavours that span diverse, top-class clinical and basic research institutes in the twin cities of Heidelberg and Mannheim.
We welcome you to interact with the vibrant neuroscience and pain community of Heidelberg-Mannheim, participate in our collaborative research efforts and inform yourself about attractive career and training options as well as key events and resources.
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Grant writing workshop
In July 2018, the Heidelberg Pain Consortium hosted a grant writing workshop for trainees and postdocs
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Überlebensstrategien - Schmerz
A collaborative effort by the University of Heidelberg and the local Rhein Neckar Zeitung, the talk series "Überlebensstrategien" introduces the interested public to research topics worked on in Heidelberg.
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Heidelberg Pain Consortium - DasGehirn.info Partnership
A collaborative effort by the University of Heidelberg and dasGehirn.info is to provide the German public with information about the workings of the nervous system. In this current article, our experts help in explaining the different qualities and identities pain and nociception can assume.
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Jan Siemens awarded ERC Consolidator Grant
Wie der körpereigene Thermostat funktioniert: Heidelberger Pharmakologe erhält ERC Consolidator Grant für Forschung zur Wärmeregulation bei Säugetieren
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Feldberg Prize 2017
Prof. Irene Tracey was awarded the 2017 Feldberg Foundation prize and chose Heidelberg for her award lecture.
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Rohini Kuner honored with HMLS Award
With the annual HMLS Investigator Award, the Heidelberg Molecular Life Sciences initiative helps establish and ensure the visibility of the Heidelberg life sciences among the top international research universities.
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Upcoming Events
| 01 Oct 201809:00AMYoung Scientist Retreat |
| 01 Oct 201809:00AMYoung Scientist Retreat |
- Brings S, Fleming T, De Buhr S, Beijer B, Lindner T, Wischnjow A, Kender Z,Peters V, Kopf S, Haberkorn U, Mier W, Nawroth PP
- A scavenger peptide prevents methylglyoxal induced pain in mice.
- Biochim Biophys Acta. 2017 Mar;1863(3):654-662. doi: 10.1016/j.bbadis.2016.12.001. PubMed PMID: 27932057.
- Flor H
- Pain has an element of blank - a biobehavioral approach to chronicity.
- Pain. 2017 Jan 18 doi: 10.1097/j.pain.0000000000000850. [Epub ahead of print] PubMed PMID: 28114184.
- Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG.
- Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination.
- Neuron. 2017 Jan 4;93(1):179-193. doi: 10.1016/j.neuron.2016.11.027. PubMed PMID: 27989460.
- Frischknecht U, Hermann D, Tunc-Skarka N, Wang GY, Sack M, van Eijk J, Demirakca T, Falfan-Melgoza C, Krumm B, Dieter S, Spanagel R, Kiefer F, Mann KF, Sommer WH, Ende G, Weber-Fahr W.
- . Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats.
- Alcohol Clin Exp Res.. 2017 Feb;41(2):323-333. doi: 10.1111/acer.13308. PubMed PMID: 28098946
- Frings S.
- Smelling better with chloride.
- Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11063-11065. PubMed PMID: 27660238.
- Schilder A, Magerl W, Hoheisel U, Klein T, Treede RD.
- Electrical high-frequency stimulation of the human thoracolumbar fascia evokes long-term potentiation-like pain amplification.
- Pain 2016 Oct;157(10):2309-17. doi: 10.1097/j.pain.0000000000000649. PubMed PMID: 27322440
- Bäumer P, Kele H, Xia A, Weiler M, Schwarz D, Bendszus M, Pham M.
- Posterior interosseous neuropathy: Supinator syndrome vs fascicular radial neuropathy. .
- Neurology 2016 Sep 28. pii: 10.1212/WNL.0000000000003287. [Epub ahead of print] PubMed PMID: 27683851.
- Song K, Wang H, Kamm GB, Pohle J, Reis FC, Heppenstall P, Wende H, Siemens J.
- The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.
- Science 2016 Sep 23;353(6306):1393-1398. PubMed PMID: 27562954.
- Obenhaus HA, Rozov A, Bertocchi I, Tang W, Kirsch J, Betz H, Sprengel R .
- Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors.
- Front Mol Neurosci 2016 Aug 30;9:75. doi: 10.3389/fnmol.2016.00075. eCollection 2016. PubMed PMID: 27625595; PubMed Central PMCID: PMC5004486.
- Mease RA, Sumser A, Sakmann B, Groh A.
- Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo.
- Cereb Cortex 2016 Aug;26(8):3461-75. doi:10.1093/cercor/bhw123. Epub 2016 May 12. PubMed PMID: 27178196; PubMed CentralPMCID: PMC4961018.
- Batti L, Sundukova M, Murana E, Pimpinella S, De Castro Reis F, Pagani F, Wang H, Pellegrino E, Perlas E, Di Angelantonio S, Ragozzino D, Heppenstall PA.
- TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States.
- Cell Rep. 2016 Jun 21;15(12):2608-15. doi: 10.1016/j.celrep.2016.05.039. PubMed PMID: 27332874; PubMed Central PMCID: PMC4921873.
- Genovese F, Thews M, Möhrlen F, Frings S .
- Properties of an optogenetic model for olfactory stimulation.
- J Physiol. 2016 Jul 1;594(13):3501-16. doi: 10.1113/JP271853. Epub 2016 Mar 17. PubMed PMID: 26857095; PubMed Central PMCID: PMC4929330.
- Cao H, Bertolino A, Walter H, Schneider M, Schäfer A, Taurisano P, Blasi G, Haddad L, Grimm O, Otto K, Dixson L, Erk S, Mohnke S, Heinz A, Romanczuk-Seiferth N, Mühleisen TW, Mattheisen M, Witt SH, Cichon S, Noethen M, Rietschel M, Tost H, Meyer-Lindenberg A.
- Altered Functional Subnetwork During Emotional Face Processing: A Potential Intermediate Phenotype for Schizophrenia.
- JAMA Psychiatry. 2016 Jun 1;73(6):598-605. doi: 10.1001/jamapsychiatry.2016.0161.PubMed PMID: 27145286.
- Pitzer C, Kuner R, Tappe-Theodor A.
- EXPRESS: Voluntary and evoked behavioral correlates in neuropathic pain states under different housing conditions.
- Mol Pain. 2016 Jun 15;12. pii: 1744806916656635. doi: 10.1177/1744806916656635. Print 2016. PubMed PMID: 27306409; PubMed Central PMCID: PMC4956152.
- Stantcheva KK, Iovino L, Dhandapani R, Martinez C, Castaldi L, Nocchi L, Perlas E, Portulano C, Pesaresi M, Shirlekar KS, de Castro Reis F, Paparountas T, Bilbao D, Heppenstall PA.
- A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.
- EMBO Rep. 2016 Apr;17(4):585-600. doi: 10.15252/embr.201540983. Epub 2016 Feb 29. PubMed PMID: 26929027; PubMed Central PMCID: PMC4818769.
- Venkataramani V, Herrmannsdörfer F, Heilemann M, Kuner T.
- SuReSim: simulating localization microscopy experiments from ground truth models.
- Nat Methods. 2016 Apr;13(4):319-21. doi: 10.1038/nmeth.3775. Epub 2016 Feb 29. PubMed PMID: 26928761.
- Nees TA, Tappe-Theodor A. , Sliwinski C, Motsch M, Rupp R, Kuner R., Weidner N,Blesch A.
- Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury.
- Pain. 2016 Mar;157(3):687-97. doi: 10.1097/j.pain.0000000000000422. PubMed PMID: 26588690.
- Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y,Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC,Chao MV, Giese G, Sprengel R. , Kuner R., Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.
- A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.
- Neuron. 2016 Mar 16;89(6):1291-304. doi: 10.1016/j.neuron.2016.01.041. Epub 2016 Mar 3. PubMed PMID: 26948889.
- Kamping S, Andoh J., Bomba IC, Diers M, Diesch E, Flor H.
- Contextual modulation of pain in masochists: involvement of the parietal operculum and insula.
- Pain. 22016 Feb;157(2):445-55. doi: 10.1097/j.pain.0000000000000390. PubMed PMID: 26808014; PubMed Central PMCID: PMC4795098.
- Zhang X, Zhong W, Brankačk J, Weyer SW, Müller UC, Tort AB, Draguhn A.
- Impaired theta-gamma coupling in APP-deficient mice.
- Sci Rep. 2016 Feb 24;6:21948. doi: 10.1038/srep21948. PubMed PMID: 26905287; PubMed Central PMCID: PMC4764939.
- Shabes P, Schloss N, Magerl W, Schmahl C, Treede RD, Baumgärtner U.
- A novel human surrogate model of noninjurious sharp mechanical pain.
- Pain. 2016 Jan;157(1):214-24. doi: 10.1097/j.pain.0000000000000352. PubMed PMID: 26397930
- Fuchs EC, Neitz A, Pinna R, Melzer S, Caputi A, Monyer H.
- Local and Distant Input Controlling Excitation in Layer II of the Medial Entorhinal Cortex.
- Neuron. 2016 Jan 6;89(1):194-208. doi: 10.1016/j.neuron.2015.11.029. Epub 2015 Dec 17. PubMed PMID: 26711115; PubMed Central PMCID: PMC4712190.
- Mease RA, Metz M, Groh A.
- Cortical Sensory Responses Are Enhanced by the Higher-Order Thalamus.
- Cell Rep. 2016 Jan 12;14(2):208-15. doi:10.1016/j.celrep.2015.12.026. Epub 2015 Dec 31. PubMed PMID: 26748702.
- Pham M. , Oikonomou D, Hornung B, Weiler M, Heiland S, Bäumer P, Kollmer J, Nawroth PP, Bendszus M.
- Magnetic resonance neurography detects diabetic neuropathy early and with Proximal Predominance.
- Ann Neurol. 2015 Dec;78(6):939-48. doi: 10.1002/ana.24524. Epub 2015 Nov 14. PubMed PMID:26381658.
- Vollert J, Mainka T, Baron R, Enax-Krumova EK, Hüllemann P, Maier C, Pfau DB, Tölle T, Treede RD .
- Quality assurance for Quantitative Sensory Testing laboratories: development and validation of an automated evaluation tool for the analysis of declared healthy samples.
- Pain. 2015 Dec;156(12):2423-30. doi:10.1097/j.pain.0000000000000300. PubMed PMID: 26580679.
- Eisenhardt M, Leixner S, Luján R, Spanagel R. , Bilbao A.
- Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior.
- Neurosci. 2015 Nov 25;35(47):15523-38. doi: 10.1523/JNEUROSCI.2970-15.2015. PubMed PMID: 26609150.
- Nunes D, Kuner T.
- Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice.
- Nat Commun. 2015 Nov 23;6:8950. doi: 10.1038/ncomms9950. PubMed PMID: 26592770; PubMed Central PMCID: PMC4673882.
- Njoo C, Agarwal N, Lutz B, Kuner R.
- The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons.
- PLoS Biol. 2015 Oct 23;13(10):e1002286. doi: 10.1371/journal.pbio.1002286. eCollection 2015 Oct. PubMed PMID: 26496209; PubMed Central PMCID: PMC4619884
- Andoh J. , Matsushita R, Zatorre RJ.
- Asymmetric Interhemispheric Transfer in the Auditory Network: Evidence from TMS, Resting-State fMRI, and Diffusion Imaging.
- JNeurosci 2015 Oct 28;35(43):14602-11. doi: 10.1523/JNEUROSCI.2333-15.2015.PubMed PMID: 26511249
- Bekrater-Bodmann R, Chung BY, Richter I, Wicking M, Foell J, Mancke F, Schmahl C, Flor H.
- Deficits in pain perception in borderline personality disorder: results from the thermal grill illusion.
- Pain. . 2015 Oct;156(10):2084-92. doi: 10.1097/j.pain.0000000000000275. PubMed PMID: 26098439; PubMed Central PMCID: PMC4770381
- Tost H, Champagne FA, Meyer-Lindenberg A.
- Environmental influence in the brain, human welfare and mental health.
- Nat Neurosci. 2015 Oct;18(10):1421-31.doi: 10.1038/nn.4108. Epub 2015 Sep 25. Review. PubMed PMID: 26404717.
- Namer B, Ørstavik K, Schmidt R, Kleggetveit IP, Weidner C, Mørk C, Kvernebo MS, Kvernebo K, Salter H, Carr TH, Segerdahl M, Quiding H, Waxman SG, Handwerker HO, Torebjörk HE, Jørum E, Schmelz M.
- Specific changes in conduction velocity recovery cycles of single nociceptors in a patient with erythromelalgia with the I848T gain-of-function mutation of Nav1.7.
- Pain. 2015 Sep;156(9):1637-46. doi: 10.1097/j.pain.0000000000000229. PubMed PMID: 25993546.
- Mauceri D. , Hagenston AM, Schramm K, Weiss U, Bading H.
- Nuclear Calcium Buffering Capacity Shapes Neuronal Architecture.
- J Biol Chem. 2015 Sep 18;290(38):23039-49. doi: 10.1074/jbc.M115.654962. Epub 2015 Jul 31. PubMed PMID: 26231212; PubMed Central PMCID: PMC4645628.
- Herpertz SC. , Bertsch K.
- A New Perspective on the Pathophysiology of BorderlinePersonality Disorder: A Model of the Role of Oxytocin.
- Am J Psychiatry. 2015 Sep 1;172(9):840-51. doi: 10.1176/appi.ajp.2015.15020216. Review. PubMed PMID:26324303
- Henrich F, Magerl W. , Klein T, Greffrath W, Treede RD.
- Capsaicin-sensitive C-and A-fibre nociceptors control long-term potentiation-like pain amplification in humans.
- Brain. 2015 Sep;138(Pt 9):2505-20. doi: 10.1093/brain/awv108. Epub 2015 May 4. PubMed PMID: 25943423.