SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganization
What underlies the ‘Dr. Jekyll and Mr. Hyde’ nature of this key physiological function that has protected the animal kingdom from harm throughout evolution?
Why does pain convert into a disorder by becoming chronic?
And importantly, can we prevent, treat or revert these changes?
These questions are at the heart of the new Heidelberg Pain Consortium. Established by the German Research Foundation at Heidelberg University in July 2015, this centre comprises nineteen multidisciplinary projects and several associated research endeavours that span diverse, top-class clinical and basic research institutes in the twin cities of Heidelberg and Mannheim.
We welcome you to interact with the vibrant neuroscience and pain community of Heidelberg-Mannheim, participate in our collaborative research efforts and inform yourself about attractive career and training options as well as key events and resources.
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Pain Summer School
"Chronic Pain and its affective consequences"
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International Satellite Symposium, "Neural Circuits of Pain - IV"
Registration deadline extended to 5 April 2022!
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Latest research from Project A06
(New paper published in Neuron)
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Junior Career Research Stipends
Application deadline: 15. September 2021
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Events
The Heidelberg Pain Consortium hosts several scientific exchange as well as public outreach events per year. Please take a look at the upcoming events below:
Upcoming Events
| 06 Dec 202208:30AMAnnual Research Symposium |
Selected Recent Events
- SFB 1158 Virtual Mini Symposium on Neural Circuits of Pain
- The Challenge of Chronic Pain Conference
- Preparatory Retreat
- Annual International Research Symposium 2018
- Young Scientists Retreat
- Grant writing workshop
- International Pain Summer School 2018
- Paincircuits
- German Pain Congress 2016
- International Pain Summer School 2016
- Asan, L., Falfán-Melgoza, C., Beretta, C.A., Sack, M., Zheng, L., Weber-Fahr, W., Kuner, T., and Knabbe, J. (2021).
- Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy.
- Scientific Reports 11, 4234.
- Kandic M, Moliadze V, Andoh J, Flor H, Nees F (in Press).
- Brain Circuits Involved in The Development of Chronic Musculoskeletal Pain: Evidence from Non-Invasive Brain Stimulation.
- Front. Neurol. doi: 10.3389/fneur.2021.732034
- Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R.
- The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
- Mol Psychiatry. 2021 Apr;26(4):1376-1398. doi: 10.1038/s41380-019-0491-4.
- Schnakenberg M, Thomas C, Schmelz M, Rukwied R.
- Nerve growth factor sensitizes nociceptors to C-fibre selective supra-threshold electrical stimuli in human skin.
- Eur J Pain. 2021;25(2):385-97.
- Bekrater-Bodman, R., Reinhardt, I., Diers, M., Fuchs, X., & Flor, H. (2021).
- Relationship of prosthesis ownership and phantom limb pain: results of a survey in 2.383 limb amputees.
- Pain, 162, 630-640.
- Schmelz M.
- What can we learn from the failure of quantitative sensory testing?
- Pain. 2021;162(3):663-4.
- Tan LL, Oswald MJ, Kuner R.
- Neurobiology of brain oscillations in acute and chronic pain.
- Trends Neurosci. 2021 Jun 16:S0166-2236(21)00097-7. doi: 10.1016/j.tins.2021.05.003. Epub ahead of print. PMID: 34176645.
- Tan LL, Kuner R.
- Neocortical circuits in pain and pain relief.
- Nat Rev Neurosci. 2021 Aug;22(8):458-471. doi: 10.1038/s41583-021-00468-2. Epub 2021 Jun 14. PMID: 34127843.
- Gan Z, Li H, Naser PV, Oswald MJ, Kuner R.
- Suppression of neuropathic pain and comorbidities by recurrent cycles of repetitive transcranial direct current motor cortex stimulation in mice.
- Sci Rep. 2021 May 6;11(1):9735. doi: 10.1038/s41598-021-89122-6. PMID: 33958647; PMCID: PMC8102487.
- Bali KK, Gandla J, Rangel DR, Castaldi L, Mouritzen P, Agarwal N, Schmelz M, Heppenstall P, Kuner R.
- A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy.
- Pain. 2021;162(5):1334-51.
- Bonalume V, Caffino L, Castelnovo LF, Faroni A, Liu S, Hu J, Milanese M, Bonanno G, Sohns K, Hoffmann T, De Col R, Schmelz M, Fumagalli F, Magnaghi V, Carr RW.
- Axonal GABAA stabilises excitability in unmyelinated sensory axons secondary to NKCC1 activity.
- J Physiol. 2021 (in press).
- Bonalume V, Caffino L, Castelnovo LF, Faroni A, Liu S, Hu J, Milanese M, Bonanno G, Sohns K, Hoffmann T, De Col R, Schmelz M, Fumagalli F, Magnaghi V, Carr R.
- Axonal GABAA stabilises excitability in unmyelinated sensory axons secondary to NKCC1 activity.
- J Physiol. 2021 Jun 26. doi: 10.1113/JP279664. Online ahead of print. PMID: 34174096
- Deshpande D, Agarwal N, Fleming T, Gaveriaux-Ruff C, Klose CSN, Tappe-Theodor A, Kuner R, Nawroth P.
- Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
- Nat Commun. 2021 Jan 18;12(1):426. doi: 10.1038/s41467-020-20677-0. Erratum in: Nat Commun. 2021 Feb 8;12(1):989. PMID: 33462216; PMCID: PMC7814083.
- Kampanis V, Tolou-Dabbaghian B, Zhou L, Roth W, Puttagunta R. (2021)
- "Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth"
- Cells 10, no. 1: 32.
- Simonetti M, Kuner R.
- Locus revealed: Painlessness via loss of NaV1.7 at central terminals of sensory neurons.
- Neuron 2021 May 5;109(9):1413-1416. doi:10.1016/j.neuron.2021.04.011. PMID: 33957067.
- Streich L., Boffi J., Wang L., Alhalaseh K., Barbieri M., Rehm R., Deivasigamani S., Gross C., Agarwal A., Prevedel R. (2021)
- High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy
- bioRxiv 2021.01.12.426323 (Nature Methods, in Press).
- Karl F, Bischler T, Egenolf N, Evdokimov D, Heckel T, Üçeyler N.
- Fibromyalgia versus small fiber neuropathy: diverse keratinocyte transcriptome signature.
- Pain. 2021 Mar 1. doi: 10.1097/j.pain.0000000000002249.
- Kreß L, Hofmann L, Klein T, Klug K, Saffer N, Spitzel M, Bär F, Sommer C, Karl F, Üçeyler N.
- Differential impact of keratinocytes and fibroblasts on nociceptor degeneration and sensitization in small fiber neuropathy.
- Pain. 2021 Apr 1;162(4):1262-1272. doi: 10.1097/j.pain.0000000000002122.
- Wahis, J., Kerspern, D., Althammer, F., Baudon, A., Goyon, S., Hagiwara, D., Lefèvre, A., Boury-Jamot, B., Bellanger, B., Abatis, M., Silva da Gouveia, M., Benusiglio, D., Marina Eliava, Rozov, A., Weinsanto, I., Knobloch-Bollmann, H.S., Wang, H., Pertin, M., Inquimbert, P., Pitzer, C., Siemens, J., Goumon, Y., Boutrel, B., Darbon, P., Lamy, C.M., Stern, J.E., Décosterd,I., Chatton, J-Y., Young, W.S., Stoop, R., Poisbeau, P., Grinevich, V.*, Charlet, A. (2021)
- Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
- Nature Neurosci., doi: 1038/s41593-021-00800-0.
- García-González D, Dumitru I, Zuccotti A, Yen TY, Herranz-Pérez V, Tan LL, Neitz A, García-Verdugo JM, Kuner R, Alfonso J, Monyer H.
- Correction: Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain. Mol Psychiatry. 2021 Jun 7. doi: 10.1038/s41380-021-01177-z. Epub ahead of print.
- Erratum for: Mol Psychiatry. 2020 Jul 1;: PMID: 34099875.
- de Kock, C.P.J., Pie, J., Pieneman, A.W. et al.
- High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.
- Commun Biol 4, 709 (2021). https://doi.org/10.1038/s42003-021-02241-8
- Kuner, R. & Kuner, T. (2020).
- Cellular circuits in the brain and their modulation in acute and chronic pain.
- Physiol Rev. DOI 10.1152/physrev.00040.2019.
- Klevanski, M., Herrmannsdörfer, F., Sass, S., Venkataramani, V., Heilemann, M. Kuner, T. (2020).
- Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues.
- Nature Communications 11:1552 | https://doi.org/10.1038/s41467-020-15362.
- Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., Kirchner, M.K., Roy, R.K., Wang, S., Eliava, M., Wagner, S., Oberhuber, M., Conzelmann, K.K., Schwarz, M., Stern, J.E., Leng, G., Neumann, I.D., Charlet, A., Grinevich, V. (2020).
- Social touch promotes inter-female communication via activation of parvocellular oxytocin neurons.
- Nature Neurosci. doi: 10.1038/s41593-020-0674.
- Nees F, Ruttorf M, Fuchs X, Rance M, Beyer N. (2020).
- Brain-behaviour correlates of habitual motivation in chronic back pain.
- Scientific Reports, 10(1), 11090. doi: 10.1038/s41598-020-67386-8.
- Boll, S., Ueltzhoeffer, K., Roth, C., Betsch, K., Desch, S., Nees, F., Grinevich, V., Herpertz, S.C. (2020).
- Pain-modulating effects of oxytocin in patients with chronic low back pain.
- Neuropharmacology, 171:108105. doi: 10.1016/j.neuropharm.2020.108105.
- Finnerup NB, Kuner R, Jensen TS.
- Neuropathic Pain: From Mechanisms to Treatment.
- Physiol Rev. 2021 Jan 1;101(1):259-301. doi: 10.1152/physrev.00045.2019. Epub 2020 Jun 25. PMID: 32584191.
- Andoh, J., Milde, C., Diers, M., Bekrater-Bodmann, R., Trojan, J., Fuchs, X., Becker, S., Desch, S. and Flor, H., 2020.
- Assessment of cortical reorganization and preserved function in phantom limb pain: a methodological perspective.
- Scientific Reports, 10(1), pp.1-15.
- Kuner R, Kuner T.
- Cellular circuits in the brain and their modulation in acute and chronic pain.
- Physiol Rev. 2020 Jun 11. doi: 10.1152/physrev.00040.2019.
- Makin, T.R. and Flor, H., 2020.
- Brain (re) organisation following amputation: Implications for phantom limb pain.
- NeuroImage, 218, p.116943.
- Netser, S., Meyer, A., Magalnik, H., Zylbertal, A., de la Zerda, S.H., Briller, M., Bizer, A., Grinevich, V.*, Wagner, S. (2020).
- Distinct dynamics of social motivation drive different patterns of social behavior in Sprague Dawley rats and C57BL/6J mice.
- Nature Commun. doi: https://doi.org/10.1038/s41467-020-19569-0
- Boll S, Ueltzhoeffer K, Roth C, Bertsch K, Desch S, Nees F, Grinevich V, Herpertz SC. (2020)
- Pain-modulating effects of oxytocin in patients with chronic low back pain.
- Neuropharmacology Jul;171:108105.
- Simonetti M , Kuner R.
- Spinal Wnt5a plays a key role in spinal dendritic spine remodeling in neuropathic and inflammatory pain models and in the pro-algesic effects of peripheral Wnt3a.
- J Neurosci. 2020 Aug 26;40(35):6664-6677. doi: 10.1523/JNEUROSCI.2942-19.2020.
- Hirth M, Gandla J, Höper C, Gaida MM, Agarwal N, Simonetti M, Demir A, Xie Y, Weiss C, Michalski CW, Hackert T, Ebert MP, Kuner R.
- CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients.
- Gastroenterology. 2020 Aug;159(2):665-681.e13. doi: 10.1053/j.gastro.2020.04.037. Epub 2020 Apr 21. PMID: 32330476.
- Semyanov A., Henneberger C., and Agarwal A. (2020)
- Making sense of astrocytic calcium signals — from acquisition to interpretation.
- Nature Reviews Neuroscience Oct;21(10):551-564.
- Yan, J., Bengtson, C.P., Buchthal, B., Hagenston, A.M., Bading, H. (2020).
- Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants.
- Science 370: eaay3302.
- Kong G, Zhou L, Serger E, Palmisano I, De Virgiliis F, Hutson TH, Mclachlan E, Freiwald A, La Montanara P, Shkura K, Puttagunta R, Di Giovanni S. (2020)
- AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury.
- Nat Metab. Sep;2(9):918-933.
- Agarwal, N., Taberner, F.J., Rangel Rojas, D., Moroni, M., Omberbasic, D., Njoo, C., Andrieux, A., Gupta, P., Bali, K.K., Herpel, E., Faghihi, F., Fleming, T., Dejean, A., Lechner, S.G., Nawroth, P.P., Lewin, G.R., Kuner, R., 2020.
- SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes.
- Neuron 107, 1141-1159.e7. https://doi.org/10.1016/j.neuron.2020.06.037
- Jonas, R., Prato, V., Lechner, S.G., Groen, G., Obreja, O., Werland, F., Rukwied, R., Klusch, A., Petersen, M., Carr, R.W., Schmelz, M., 2020.
- TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors.
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- TTX-Resistant Sodium Channels Functionally Separate Silent From Polymodal C-nociceptors.
- Front Cell Neurosci. 2020;14(13):13.
- Rukwied R, Thomas C, Obreja O, Werland F, Kleggetveit IP, Jorum E, Carr RW, Namer B, Schmelz M.
- Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin.
- Pain. 2020;161(9):2119-28.
- Johann ME Jende, Jan B Groener, Zoltan Kender, Artur Hahn, Jakob Morgenstern, Sabine Heiland, Peter P Nawroth, Martin Bendszus, Stefan Kopf, Felix T Kurz
- Troponin T Parallels Structural Nerve Damage in Type 2 Diabetes: A Cross-sectional Study Using Magnetic Resonance Neurography.
- Diabetes 2020 Apr;69(4):713-723.
- Jan B Groener, Johann M E Jende, Felix T Kurz, Zoltan Kender, Rolf-Detlef Treede, Sigrid Schuh-Hofer, Peter P Nawroth, Martin Bendszus, Stefan Kopf
- Understanding Diabetic Neuropathy-From Subclinical Nerve Lesions to Severe Nerve Fiber Deficits: A Cross-Sectional Study in Patients With Type 2 Diabetes and Healthy Control Subjects
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- Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C.
- A bi-directional neural progenitor – endothelial cell crosstalk regulates oligodendrocyte precursor cell specification.
- Nat Neurosci. 2020, accepted.
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- Oxytocin and positive couple interaction affect the perception of wound pain in everyday life.
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- The evaluation and brain representation of pleasant touch in chronic and subacute back pain.
- Neurobiology of Pain 2019; 5:100025.(B03 project-specific)
- Katrin Schrenk-Siemens, Jörg Pohle, Charlotte Rostock, Muad Abd El Hay, Ruby M. Lam, Marcin Szczot, Shiying Lu, Alexander T. Chesler, Jan Siemens;
- HESC-derived sensory neurons reveal an unexpected role for PIEZO2 in nociceptor mechanotransduction.
- bioRxiv, August 2019, doi: https://doi.org/10.1101/741660.
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- A common ground for pain and depression.
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- Bilbao A, Cantacorps L, Leixner S, Wei S, Valverde O, Spanagel R.
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- Management of pain in individuals with spinal cord injury: Guideline of the German-Speaking Medical Society for Spinal Cord Injury.
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- Neural network-based alterations during repetitive heat pain stimulation in major depression.
- Eur Neuropsychopharmacol, 29(9), 1033-1040. doi:10.1016/j.euroneuro.2019.06.011
- Oliveira AM, Litke C, Paldy E, Hagenston AM, Lu J, Kuner R, Bading H, Mauceri D.
- Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2.
- Mol Pain. 2019 Jan-Dec;15. doi: 10.1177/1744806919827469.
- Evdokimov D, Frank J, Klitsch A, Unterecker S, Warrings B, Serra J, Papagianni A, Saffer N, Meyer Zu Altenschildesche C, Kampik D, Malik RA, Sommer C, Üçeyler N.
- Reduction of skin innervation is associated with a severe fibromyalgia phenotype.
- Ann Neurol. 2019 Oct;86(4):504-516. doi: 10.1002/ana.25565.
- Held M, Karl F, Vlckova E, Rajdova A, Escolano-Lozano F, Stetter C, Bharti R, Förstner KU, Leinders M, Dušek L, Birklein F, Bednarik J, Sommer C, Üçeyler N.
- Sensory profiles and immune related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion.
- Pain. 2019 May 22. doi: 10.1097/j.pain.0000000000001623.
- Hasan, M.T., Althammer, F., da Silva Gouveia, M., Goyon, S., Eliava, M., Lefevre, A., Kerspern, D., Schimmer, J., Raftogianni, A., Wahis, J., Knobloch-Bollmann, H.S., Tang, Y., Liu, X., Jain, A., Chavant, V., Goumon, Y., Weislogel, J.-M., Hurlemann, R., Herpertz, S.C., Pitzer, C., Darbon, P., Dogbevia, G.K., Bertocchi, I., Larkum, M.E., Sprengel, R., Bading, H., Charlet, A. and Grinevich, V. (2019).
- A fear memory engram and its plasticity in the hypothalamic oxytocin system.
- Neuron, 103, 133-146. https://doi.org/10.1016/j.neuron.2019.04.029.
- Tan LL, Oswald MO, Heinl C, Retana OR, Kaushalya S, Monyer H and Kuner R
- Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
- Nature Communications 2019 Feb 28;10(1):983. doi: 10.1038/s41467-019-08873-z.
- Bilbao A, Leixner S, Wei S, Cantacorps L, Valverde O, Spanagel R
- Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain
- Addiction Biology 2019 Sep;24(5):1008-1018. doi: 10.1111/adb.12784. Epub 2019 Jun 25
- Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA.
- Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons.
- Nat Commun 2018;9:1640.
- Schuh-Hofer S, Fischer J, Unterberg A, Treede RD,Ahmadi R.
- Spinal cord stimulation modulates descending pain inhibition and temporal summation of pricking pain in patients with neuropathic pain.
- Acta Neurochir 2018; doi: 10.1007/s00701-018-3669-7. [Epub ahead of print]
- Nees F, Usai K, Löffler M, Flor H
- The evaluation and brain representation of pleasant touch in chronic and subacute back pain
- Neurobiology of Pain 2018 Oct 29;5:100025. doi: 10.1016/j.ynpai.2018.10.002. eCollection Jan-Jul 2019.
- Nees F, Löffler M, Usai K, Flor H.
- Hypothalamic-pituitary-adrenal axis feedback sensitivity in different states of back pain.
- Psychoneuroendocrinology 2019 Mar;101:60-66. doi: 10.1016/j.psyneuen.2018.10.026. Epub 2018 Oct 26.
- Oliveira AMM, Litke C, Paldy E, Hagenston AM, Lu J, Kuner R, Bading H and Mauceri D
- Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2.
- Molecular Pain 2019 Jan-Dec;15:1744806919827469. doi: 10.1177/1744806919827469.
- Frank TB, Kuner R and Nawroth PP
- Structure-function Relationships in Peripheral Nerve Contributions to Diabetic Peripheral Neuropathy
- Pain 2019 May;160 Suppl 1:S29-S36. doi: 10.1097/j.pain.0000000000001530.
- Pitzer C, La Porta C, Treede RD, Tappe-Theodor A.
- Inflammatory and neuropathic pain conditions do not primarily evoke anxiety-like behaviours in C57BL/6 mice.
- Eur J Pain. 2019 Feb;23(2):285-306. doi: 10.1002/ejp.1303. Epub 2018 Sep 3.
- Sachau J, Bruckmueller H, Gierthmühlen J, Magerl W, Kaehler M, Haenisch S, Binder A, Caliebe A, Maier C, Treede RD, Tölle T, Cascorbi I, Baron R.
- SIGMA-1 Receptor Gene Variants Affect the Somatosensory Phenotype in Neuropathic Pain Patients.
- J Pain 2019 Feb;20(2):201-214. doi: 10.1016/j.jpain.2018.08.011. Epub 2018 Sep 25.
- Carr R, Frings S.
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