Publications

Breyer M, Klein T, Klug K, Klopocki E, Üçeyler N. Generation of the induced pluripotent stem cell line UKWNLi005-A derived from a patient with the GLA mutation c.376A > G of unknown pathogenicity in Fabry disease. Stem Cell Res. 2022 May;61:102747. doi: 10.1016/j.scr.2022.102747.

Lau K, Üçeyler N, Cairns T, Lorenz L, Sommer C, Schindehütte M, Amann K, Wanner C, Nordbeck P. Gene variants of unknown significance in Fabry disease: Clinical characteristics of c.376A>G (p.Ser126Gly). Mol Genet Genomic Med. 2022 May;10(5):e1912. doi: 10.1002/mgg3.1912. Epub 2022 Feb 25.

Spitzel M, Wagner E, Breyer M, Henniger D, Bayin M, Hofmann L, Mauceri D, Sommer C, Üçeyler N. Dysregulation of immune response mediators and pain-related ion channels is associated with pain-like behavior in the GLA KO mouse model of Fabry disease. Cells. 2022 May 24;11(11):1730.  doi:10.3390/cells11111730.

Wagenhäuser L, Rickert V, Sommer C, Wanner C, Nordbeck P, Rost S, Üçeyler N. X-chromosomal inactivation patterns in women with Fabry disease. Mol Genet Genomic Med. 2022 Sep;10(9):e2029. doi: 10.1002/mgg3.2029. Epub 2022 Aug 16.

Weiner S, Strinitz M, Herfurth J, Hessenauer F, Nauroth-Kreß C, Kampf T, Homola GA, Üçeyler N, Sommer C, Pham M, Schindehütte M. Dorsal root ganglion volumetry by MR gangliography. AJNR Am J Neuroradiol. 2022 May;43(5):769-775. doi: 10.3174/ajnr.A7487. Epub 2022 Apr 21.

Karl F, Bischler T, Egenolf N, Evdokimov D, Heckel T, Üçeyler N. Fibromyalgia versus small fiber neuropathy: diverse keratinocyte transcriptome signature. Pain. 2021 Mar 1. doi: 10.1097/j.pain.0000000000002249. (project-related)

Kreß L, Hofmann L, Klein T, Klug K, Saffer N, Spitzel M, Bär F, Sommer C, Karl F, Üçeyler N. Differential impact of keratinocytes and fibroblasts on nociceptor degeneration and sensitization in small fiber neuropathy. Pain. 2021 Apr 1;162(4):1262-1272. doi: 10.1097/j.pain.0000000000002122. (project-related)

Lenders M, Nordbeck P, Kurschat C, Eveslage M, Karabul N, Kaufeld J, Hennermann JB, Patten M, Cybulla M, Müntze J, Üçeyler N, Liu D, Das AM, Sommer C, Pogoda C, Reiermann S, Duning T, Gaedeke J, von Cossel K, Blaschke D, Brand SM, Alexander Mann W, Kampmann C, Muschol N, Canaan-Kühl S, Brand E. Treatment of fabry disease with migalastat-outcome from a prospective 24 months observational multicenter study (FAMOUS). Eur Heart J Cardiovasc Pharmacother. 2021 Mar 16:pvab025. doi: 10.1093/ehjcvp/pvab025. (project-related)

Lenders M, Nordbeck P, Kurschat C, Karabul N, Kaufeld J, Hennermann JB, Patten M, Cybulla M, Müntze J, Üçeyler N, Liu D, Das AM, Sommer C, Pogoda C, Reiermann S, Duning T, Gaedeke J, Stumpfe K, Blaschke D, Brand SM, Mann WA, Kampmann C, Muschol N, Canaan-Kühl S, Brand E. Treatment of Fabry's Disease With Migalastat: Outcome From a Prospective Observational Multicenter Study (FAMOUS). Clin Pharmacol Ther. 2020 Aug;108(2):326-337. doi: 10.1002/cpt.1832. (project-related)

Rickert V, Wagenhäuser L, Nordbeck P, Wanner C, Sommer C, Rost S, Üçeyler N. Stratification of Fabry mutations in clinical practice: a closer look at alpha-galactosidase A-3D structure. J Intern Med. 2020 Nov;288(5):593-604. doi: 10.1111/joim.13125. (project-relevant)

Rickert V, Kramer D, Schubert AL, Sommer C, Wischmeyer E, Üçeyler N. Globotriaosylceramide-induced reduction of K(Ca)1.1 channel activity and activation of the Notch1 signaling pathway in skin fibroblasts of male Fabry patients with pain. Exp Neurol. 2020 Feb;324:113134. doi: 10.1016/j.expneurol.2019.113134. (project-relevant)

Jovanovic A, Klassen P, Heuschmann P, Sommer C, Roberts M, Üçeyler N. English version of the self-administered Fabry Pain Questionnaire for adult patients. Orphanet J Rare Dis. 2020 Oct 20;15(1):296. doi: 10.1186/s13023-020-01580-9. (project-related)

Siedler G, Káhn AK, Weidemann F, Wanner C, Sommer C, Üçeyler N. Dyshidrosis is associated with reduced amplitudes in electrically evoked pain-related potentials in women with Fabry disease. Clin Neurophysiol. 2019;130(4):528-536. doi: 10.1016/j.clinph.2019.01.008.

Üçeyler N, Urlaub D, Mayer C, Uehlein S, Held M, Sommer C. Tumor necrosis factor-α links heat and inflammation with Fabry pain. Mol Genet Metab. 2019. pii: S1096-7192(19)30169-6.

Klein T, Günther K, Kwong CK, Edenhofer F, Üçeyler N. Generation of the human induced pluripotent stem cell line (UKWNLi001-A) from skin fibroblasts of a woman with Fabry disease carrying the X-chromosomal heterozygous c.708 G > C (W236C) missense mutation in exon 5 of the alpha-galactosidase-A gene. Stem Cell Res. 2018;31:222-226.

Hofmann L, Hose D, Grießhammer A, Blum R, Döring F, Dib-Hajj S, Waxman S, Sommer C, Wischmeyer E,Üçeyler N. Characterisation of a mouse model of Fabry disease. Elife. 2018;ePub 10/17. 

Godel T, Bäumer P, Pham M, Köhn A, Muschol N, Kronlage M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Human dorsal-root-ganglion in-vivo morphometry and perfusion in Fabry painful neuropathy. Neurology. 2017;89:1274-1282.

Godel T, Pham M, Heiland S, Bendszus M, Bäumer P. Human dorsal-root-ganglion perfusion measured in-vivo by MRI. Neuroimage. 2016;141:81-87.

Üçeyler N, Biko L, Hose D, Hofmann L, Sommer C. Comprehensive and differential long-term characterization of the alpha-galactosidase A deficient mouse model of Fabry disease focusing on the sensory system and pain development. Mol Pain. 2016;12.

Pham M, Oikonomou D, Hornung B, Weiler M, Heiland S, Bäumer P, Kollmer J, Nawroth PPBendszus M.  MR neurography detects diabetic neuropathy early and with proximal predominance. Ann Neurol. 2015;78:939-948.

Üçeyler N, Magg B, Thomas P, Wiedmann S, Heuschmann P, Sommer C. A comprehensive Fabry-related pain questionnaire for adult patients. Pain. 2014;155:2301-2305. 

Üçeyler N, Ganendiran S, Kramer D, Sommer C. Characterization of pain in Fabry disease. Clin J Pain. 2014;30:915-920.

Üçeyler N, He L, Schönfeld D, Kahn AK, Reiners K, Hilz MJ, Breunig F, Sommer C. Small fibers in Fabry disease: baseline and follow-up data under enzyme replacement therapy. J Peripher Nerv Syst. 2011;16:304-314.

Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Gierthmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Üçeyler N, Valet M, Wasner G, Treede RD. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain. 2010;150:439-450. 

Other publications:

Üçeyler group:

Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, Üçeyler N. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020 Dec 1;95(22):1005-1014. doi: 10.1212/WNL.0000000000010988

Evdokimov D, Frank J, Klitsch A, Unterecker S, Warrings B, Serra J, Papagianni A, Saffer N, Meyer Zu Altenschildesche C, Kampik D, Malik RA, Sommer C, Üçeyler N. Reduction of skin innervation is associated with a severe fibromyalgia phenotype. Ann Neurol. 2019 Oct;86(4):504-516. doi: 10.1002/ana.25565.

Characterization of small fiber pathology in a mouse model of Fabry disease. Hofmann L, Hose D, Grießhammer A, Blum R, Döring F, Dib-Hajj S, Waxman S, Sommer C, Wischmeyer E, Üçeyler N. Elife. 2018 Oct 17;7. pii: e39300. doi: 10.7554/eLife.39300.

Sensory profiles and immune related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion. Held M, Karl F, Vlckova E, Rajdova A, Escolano-Lozano F, Stetter C, Bharti R, Förstner KU, Leinders M, Dušek L, Birklein F, Bednarik J, Sommer C, Üçeyler N. Pain. 2019 May 22. doi: 10.1097/j.pain.0000000000001623. 

Detection of blood Gb3 deposits as a new tool for diagnosis and therapy monitoring in patients with classic Fabry disease. Üçeyler N, Böttger J, Henkel L, Langjahr M, Mayer C, Nordbeck P, Wanner C, Sommer C. J Intern Med. 2018 Oct;284(4):427-438. doi: 10.1111/joim.12801. 

Ullrich M, Weber M, Post AM, Popp S, Grein J, Zechner M, Guerrero González H, Kreis A, Schmitt AG, Üçeyler N, Lesch KP, Schuh K. OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency. Mol Psychiatry. 2018 Feb;23(2):444-458. doi: 10.1038/mp.2016.232.

Sommer group:

Doppler K, Appeltshauser L, Villmann C, Martin C, Peles E, Kramer HH, Haarmann A, Buttmann M, Sommer C. Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy. Brain 2016;139:2617-30.

Attal N, de Andrade DC, Adam F, Ranoux D, Teixeira MJ, Galhardoni R, Raicher I, Üçeyler N, Sommer C, Bouhassira D. Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2016;15:555-65.

Sommer C. Exploring pain pathophysiology in patients. Science 2016;354:588-92.

Sommer C. Peripheral neuropathies: Long-term opioid therapy in neuropathy: benefit or harm? Nat Rev Neurol 2017;13:516-7.

Pham group:

Hoffmann A, Dege T, Kunze R, Ernst AS, Lorenz H, Böhler LI, Korff T, Marti HH, Heiland S, Bendszus M, Helluy X, Pham MEarly Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules.Stroke.2018 Jun;49(6):1479-1487. 

Bäumer P, Kele H, Xia A, Weiler M, Schwarz D, Bendszus M, Pham MPosterior interosseous neuropathy: Supinator syndrome vs fascicular radial neuropathy.Neurology. 2016 Nov 1;87(18):1884-1891

Godel T, Pham M, Heiland S, Bendszus M, Bäumer P. Human dorsal-root-ganglion perfusion measured in-vivo by MRI.Neuroimage. 2016 Nov 1;141:81-87

Hoffmann A, Pfeil J, Alfonso J, Kurz FT, Sahm F, Heiland S, Monyer H, Bendszus M, Mueller AK, Helluy X, Pham M. Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream.PLoS Pathog. 2016 Mar 10;12(3):e1005470

Pham M, Oikonomou D, Hornung B, Weiler M, Heiland S, Bäumer P, Kollmer J, Nawroth PP, Bendszus M. Magnetic resonance neurography detects diabetic neuropathy early and with Proximal Predominance.Ann Neurol. 2015 Dec;78(6):939-48

Kollmer J, Hund E, Hornung B, Hegenbart U, Schönland SO, Kimmich C, Kristen AV, Purrucker J, Röcken C, Heiland S, Bendszus M, Pham MIn vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography.

Brain. 2015 Mar;138(Pt 3):549-62. doi: 10.1093/brain/awu344. Epub 2014 Dec 18.

News

  • New collaborative research results

    Published in Science

     

    Read more ...  
  • ERC Synergy Grant 2022

    Congratulations to Prof. Dr. Valery Grinevich!

     

    Read more ...  
  • John J. Bonica Prize of the IASP

    Congratulations to Prof. Dr. Rolf Detlef-Treede!

     

    Read more ...  
  • New paper published in Nature

    Collaboration involving Projects A01, A03, B01, B06 and B08.

     

    Read more ...  
  • Pain Summer School

    "Chronic Pain and its affective consequences"

     

    Read more ...