Jun.-Prof. Dr. Daniela Mauceri

Department of Neurobiology, Bioscience Faculty, Heidelberg University

Prof. Dr. Carmen Ruiz-de-Almodovar

European Center for Angioscience, Institute for Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University

 

Pain-associated epigenetic alterations and spinal sensitization: role of the neurovascular unit
 

Long-lasting alterations of epigenetic processes in dorsal horn are causally linked to sensitization in chronic pain. How these long-lasting changes are modulated is still not defined. Alterations in the neurovascular unit (NVU) have not been thoroughly investigated in the context of chronic pain. Moreover, how the NVU might impact neuronal epigenetic processes, thereby sustaining maladaptive changes, is also elusive.
 
Key Questions:
  1. 1. Is the NVU in the spinal cord altered in chronic pain?
  2. 2. Which NVU related factors are affecting epigenetic changes in spinal cord dorsal horn neurons?
  3. 3.Do alterations of the NVU functionality contribute to epigenetic changes and to the establishment and maintenance of hypersensitivity?”

     

News

  • New research findings from the Grinevich Lab (Project B02)

    (New paper published in Nature Neuroscience)

     

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  • New discovery in the pathophysiology of diabetic neuropathy

    (New paper published in Neuron)

     

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  • Gender equality in science and career development

    Supporting the work of the ALBA Network

     

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  • The Heidelberg Outpatient Center for Clinical Pain Research (HeiSIS)

    Congratulations to SFB 1158 Project Leader, Prof. Dr. Jonas Tesarz, on becoming the Head of a new facility in his department: The "Heidelberg Outpatient Center for Clinical Pain Research (HeiSIS)"

     

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  • Dr. Frauke Nees accepts new position in Kiel

    Congratulations to Dr. Frauke Nees, one of the Consortium's PIs, on her new position as the Director of the Institute of Medical Psychology and Medical Sociology and W3 Professorship for Medical Psychology and Behavioral Neurobiology in the Medical Faculty of the Christian-Albrechts University in Kiel.