What underlies the ‘Dr. Jekyll and Mr. Hyde’ nature of this key physiological function that has protected the animal kingdom from harm throughout evolution?
Why does pain convert into a disorder by becoming chronic?
And importantly, can we prevent, treat or revert these changes?
These questions are at the heart of new research in the Collaborative Research Centre 1158 (SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganization). Established by the German Research Foundation at Heidelberg University in July 2015, this centre comprises nineteen multidisciplinary projects and several associated research endeavours that span diverse, top-class clinical and basic research institutes in the twin cities of Heidelberg and Mannheim.
We welcome you to interact with the vibrant neuroscience and pain community of Heidelberg-Mannheim, participate in our collaborative research efforts and inform yourself about attractive career and training options as well as key events and resources.
Meet SFB1158 at the World Congress on Pain
Read more ...
Allan Basbaum, Irene Tracey and Tor Wager to visit SFB1158
The Heidelberg Pain Consortium is delighted about the upcoming visit from these distinguished scientists in the framework of the upcoming Annual International Pain SymposiumRead more ...
SFB Researchers to be honored with the DGSS Förderpreis 2016
Deepitha Selvaraj and Vijayan Gangadharan (A03) will be the recipients of the DGSS Förderpreis 2016 for pain research in Germany.Read more ...
Mini symposium “Neural Circuits in Pain”
SFB project leaders regularly present their on-going research in a very well-visited mini-symposium series.Read more ...
Herta Flor to receive John D. Loeser Award
The IASP will honor Herta Flors achievements in the pain field ....Read more ...
International Pain Summer School
In July 2016, the first International Pain Summer School took place in Prien am Chiemsee, Germany.Read more ...
On June 16, 2016 SFB 1158 hosted this year's research day on neural circuits.Read more ...
German Brain Bee 2016
On April 16th the German Brain Bee Competition took place in Heidelberg.Read more ...
Annual Pain Symposium 2015
With nearly half of year of funding behind us, it was time to take stock of our scientific progress and bring in external experts to give us feedback.Read more ...
As part of the Collaborative Research Centers public outreach, several events are held each year. You can find the upcoming events below:
|26 Sep 201612:00AMWorld Congress on Pain|
|01 Dec 201608:00AMGender Symposium|
|02 Dec 201608:00AMAnnual International research Symposium|
- Mini symposium “Neural Circuits in Pain”
- Research Day
- German Brain Bee 2016
- Annual Pain Symposium 2015
- Njoo C, Agarwal N, Lutz B, Kuner R
- The cannabinoid receptor CB1 interacts with the WAVE1 complex and plays a role in actin dynamics and structural plasticity in neurons.
- PLoS Biol 13(10):e1002286, 2015
- Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R
- A functional role for VEGFR1 expressed in peripheral sensory neurons in cancer pain.
- Cancer Cell 27:780-96, 2015
- Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R
A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun 6:6820, 2015
- Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M,Kuner R
The serine protease inhibitor Serpin A3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med 21:518-23, 2015
- Selvaraj D, Kuner R
Molecular players of tumor-nerve interactions. Pain 156:6-7, 2015
- Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R
Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice. Nat Commun 5:5472, 2014