SFB 1158: From nociception to chronic pain: Structure-function properties of neural pathways and their reorganization
What underlies the ‘Dr. Jekyll and Mr. Hyde’ nature of this key physiological function that has protected the animal kingdom from harm throughout evolution?
Why does pain convert into a disorder by becoming chronic?
And importantly, can we prevent, treat or revert these changes?
These questions are at the heart of the new Heidelberg Pain Consortium. Established by the German Research Foundation at Heidelberg University in July 2015, this centre comprises nineteen multidisciplinary projects and several associated research endeavours that span diverse, top-class clinical and basic research institutes in the twin cities of Heidelberg and Mannheim.
We welcome you to interact with the vibrant neuroscience and pain community of Heidelberg-Mannheim, participate in our collaborative research efforts and inform yourself about attractive career and training options as well as key events and resources.
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Bonn Researchers Identify Key Proteins for the Repair of Nerve Fibers
Prof. Dr. Frank Bradke, and his colleagues at the German Center for Neurodegenerative Diseases (DZNE) have identified a group of proteins that help to regenerate damaged nerve cells.
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Memory engrams discovered in the hypothalamus
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Congratulations!
The Heidelberg Pain Consortium goes into the second funding period.
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Valery Grinevich appointed Professor for Neuropeptide research in psychiatry
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Events
The Heidelberg Pain Consortium hosts several scientific exchange as well as public outreach events per year. Please take a look at the upcoming events below:
Upcoming Events
| 19 Nov 201912:00PMZI colloquium |
| 02 Dec 201901:00PMGender and Science symposium |
| 03 Dec 201909:00AMAnnual international Symposium |
| 11 Dec 201901:00PMIZN seminar |
Selected Recent Events
- The Challenge of Chronic Pain Conference
- Preparatory Retreat
- Annual International Research Symposium 2018
- Young Scientists Retreat
- Grant writing workshop
- International Pain Summer School 2018
- Paincircuits
- German Pain Congress 2016
- International Pain Summer School 2016
- Tan LL, Oswald MO, Heinl C, Retana OR, Kaushalya S, Monyer H and Kuner R
- Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
- Nature Communications in press
- Bilbao A, Leixner S, Wei S, Cantacorps L, Valverde O, Spanagel R
- Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain
- Addiction Biology in press
- Nees F, Usai K, Löffler M, Flor H
- The evaluation and brain representation of pleasant touch in chronic and subacute back pain
- Neurobiology of Pain in press
- Nees F, Löffler M, Usai K, Flor H.
- Hypothalamic-pituitary-adrenal axis feedback sensitivity in different states of back pain.
- Psychoneuroendocrinology 2019 Mar;101:60-66. doi: 10.1016/j.psyneuen.2018.10.026. Epub 2018 Oct 26.
- Oliveira AMM, Litke C, Paldy E, Hagenston AM, Lu J, Kuner R, Bading H and Mauceri D
- Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2.
- Molecular Pain 2019 Jan-Dec;15:1744806919827469. doi: 10.1177/1744806919827469.
- Frank TB, Kuner R and Nawroth PP
- Structure-function Relationships in Peripheral Nerve Contributions to Diabetic Peripheral Neuropathy
- Pain in press
- Pitzer C, La Porta C, Treede RD, Tappe-Theodor A.
- Inflammatory and neuropathic pain conditions do not primarily evoke anxiety-like behaviours in C57BL/6 mice.
- Eur J Pain. 2019 Feb;23(2):285-306. doi: 10.1002/ejp.1303. Epub 2018 Sep 3.
- Sachau J, Bruckmueller H, Gierthmühlen J, Magerl W, Kaehler M, Haenisch S, Binder A, Caliebe A, Maier C, Treede RD, Tölle T, Cascorbi I, Baron R.
- SIGMA-1 Receptor Gene Variants Affect the Somatosensory Phenotype in Neuropathic Pain Patients.
- J Pain 2019 Feb;20(2):201-214. doi: 10.1016/j.jpain.2018.08.011. Epub 2018 Sep 25.
- Carr R, Frings S.
- Neuropeptides in sensory signal processing.
- Cell Tissue Res. 2019 Jan;375(1):217-225. doi: 10.1007/s00441-018-2946-3. Epub 2018 Oct 30. Review.
- Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JW, Wang SJ
- Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases ICD-11.
- Pain 2019; 160 (1)
- Obreja O, Rukwied R, Nagler L, Schmidt M, Schmelz M, Namer B.
- Nerve growth factor locally sensitises nociceptors in human skin.
- PAIN 2018;159(3):416-426.
- Sauerstein K, Liebelt J, Namer B, Schmidt R, Rukwied R, Schmelz M.
- Low-Frequency Stimulation of Silent Nociceptors Induces Secondary Mechanical Hyperalgesia in Human Skin.
- NEUROSCIENCE 2018; 387:4-12.
- Bilbao A, Falfan-Melgoza C, Leixner S, Becker R, Singaravelu SK, Sack M, Sartorius A, Spanagel R, Weber-Fahr W.
- Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain
- Neuroscience 2018;S0306-4522(18):30271-9.
- Groh A, Krieger P, Mease RA, Henderson L.
- Acute and Chronic Pain Processing in the Thalamocortical System of Humans and Animal Models.
- Neuroscience 2018;387:58-71.
- Nawroth PP, Bendszus M, Pham M, Jende J, Heiland S, Ries S, Schumann C, Schmelz M, Schuh-Hofer S, Treede RD, Kuner R, Oikonomou D, Groener JB, Kopf S.
- The Quest for more Research on Painful Diabetic Neuropathy.
- Neuroscience 2018;387:28-37.
- Rostock C, Schrenk-Siemens K, Pohle J, Siemens J.
- Human vs. Mouse Nociceptors - Similarities and Differences.
- Neuroscience 2018;387:13-27.
- Boll S, Almeida de Minas AC, Raftogianni A, Herpertz SC, Grinevich V.
- Oxytocin and Pain Perception: From Animal Models to Human Research.
- Neuroscience 2018; 387: p. 149-161.
- Kuner R, Flor H.
- Neural circuits of chronic pain
- Neuroscience 2018;387:1-3.
- Cao H, Harneit A, Walter H, Erk S, Braun U, Moessnang C, Geiger LS, Zang Z, Mohnke S, Heinz A, Romanczuk-Seiferth N, M�hleisen T, Mattheisen M, Witt SH, Cichon S, N�then MM, Rietschel M, Meyer-Lindenberg A, Tost H.
- The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.
- Neuropsychopharmacology 2018;43(2):406-14.
- Schweiger JI, Bilek E, Sch�fer A, Braun U, Moessnang C, Harneit A, Post P, Otto K, Romanczuk-Seiferth N, Erk S, Wackerhagen C, Mattheisen M, M�hleisen TW, Cichon S, N�then MM, Frank J, Witt SH, Rietschel M, Heinz A, Walter H, Meyer-Lindenberg A, Tost H
- Effects of BDNF Val66Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.
- Neuropsychopharmacology 2018 Oct 25. doi:10.1038/s41386-018-0248-9.
- Naser PV and Kuner R.
- Peripheral Kappa Opioid Receptor Signaling Takes on a Central Role.
- Neuron 99(6):1102-1104, 2018
- Grinevich V, Stoop R
- Interplay between oxytocin and sensory systems in the orchestration of socioemotional behaviour
- Neuron2018; 99:887-904
- Braun U, Schaefer A, Betzel RF, Tost H, Meyer-Lindenberg A, Bassett DS.
- From Maps to Multi-dimensional Network Mechanisms of Mental Disorders.
- Neuron 2018;97(1):14-31.
- Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA.
- Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
- Nature Commun2018;9:1640.
- Agarwal N, Helmstaedter JP, Rangel Roja D, Kumar Bali K, Gangadharan V, Kuner R.
- [EXPRESS] Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice
- Molecular Pain 2018:1744806918817975
- Sch�fer I, Prato V, Arcourt A, Taberner FJ, Lechner SG.
- Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors.
- Mol Pain2018
- Knabbe J, Nassal JP, Verhage M, Kuner T
- Secretory vesicle trafficking in awake and anaesthetized mice: differential speeds in axons versus synapses
- J Physiol. 2018; doi: 10.1113/JP276022.
- Sliwinski C, Nees TA, Puttagunta R, Weidner N, Blesch A
- Sensorimotor Activity Partially Ameliorates Pain and Reduces Nociceptive Fiber Density in the Chronically Injured Spinal Cord.
- J Neurotrauma 2018;35(18):2222-2238.
- Litke C, Bading H, Mauceri D.
- Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D.
- J Biol Chem 2018;293(21):8196-8207.
- Koch ED, Tost H, Braun U, Gan G, Giurgiu M, Reinhard I, Zipf A, Meyer-Lindenberg A, Ebner-Priemer UW, Reichert M.
- Mood Dimensions Show Distinct Within-Subject Associations With Non-exercise Activity in Adolescents: An Ambulatory Assessment Study.
- Frontiers in Psychology 2018;9:268.
- Boffi JC, Knabbe J, Kaiser M, Kuner T
- KCC2-dependent Steady-state Intracellular Chloride Concentration and pH in Cortical Layer 2/3 Neurons of Anesthetized and Awake Mice.
- Front Cell Neurosci. 2018; 12:7. doi: 10.3389/fncel.2018.00007.
- Schuh-Hofer S, Eichhorn N, Grinevich V, Treede R-D
- Sleep deprivation related changes of plasma oxytocin in males and female contraceptive users depend on sex and correlate differentially with anxiety and pain hypersensitivity.
- Front Behav Neuroscience2018; 12: 161
- Sandner B, Puttagunta R, Motsch M, Bradke F, Ruschel J, Blesch A and Weidner N.
- Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats.
- Exp Neuro 2018; 306:250-259.
- Pitzer C, La Porta C, Treede RD, Tappe-Theodor A.
- Inflammatory and neuropathic pain conditions do not primarily evoke anxiety-like behaviours in C57BL/6 mice.
- Eur J Pain 2018; doi: 10.1002/ejp.1303.
- Kopf S, Groener JB, Kender Z, Fleming T, Bischoff S, Jende J, Schumann C, Ries S, ??ends??us ??, Schuh-Hofer S, Treede RD, Nawroth PP.
- Deep phenotyping neuropathy: An underestimated complication in patients with pre-diabetes and type 2 diabetes associated with albuminuria.
- Diabetes Res Clin Pract2018; doi: 10.1016/j.diabres.2018.10.020.
- Andersen ST, Witte DR, Dalsgaard EM, Andersen H, Nawroth P, Fleming T, Jensen TM, Finnerup NB, Jensen TS, Lauritzen T, Feldman EL, Callaghan BC, Charles M.
- Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark
- Diabetes Care 2018;41(5):1068-1075.
- Menon R, Grund, T, Zoicas, Althammer F, Fiedler D, Biermeier V, Bosch OJ, Hiraoka Y, Nishimori K, Eliava M, Grinevich V, Neumann ID
- Enhanced oxytocin signaling in the lateral septum prevents social fear expression during lactation.
- Cur. Biology2018; 28: 1066-1078
- Chandrasekar A, Olde Heuvel F, Tar L, Hagenston AM, Palmer A, Linkus B, Ludolph AC, Huber-Lang M, Boeckers T, Bading H, Roselli F.
- Parvalbumin Interneurons Shape Neuronal Vulnerability in Blunt TBI.
- Cereb Cortex 2018.
- Heuser K, Nome CG, Pettersen KH, Abjorsbraten KS, Jensen V, Tang W, Sprengel R, Tauboll E, Nagelhus EA, and Enger R
- Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity.
- Cereb CortexCereb Cortex.2018
- Carr RW, Frings S.
- Neuropeptides in Sensory System Signaling.
- Cell Tiss Res 2018; DOI: 10.1007/s00441-018-2946-3.
- Jende JME, Groener JB, Oikonomou D, Heiland S, Kopf S, Pham M, Nawroth P, Bendszus M, Kurz FT.
- Diabetic neuropathy differs between type 1 and type 2 diabetes: Insights from magnetic resonance neurography.
- Annals of Neurology 2018;83(3):588-598.
- Jonas R, Namer B, Stockinger L, Chisholm K, Schnakenberg M, Landmann G, Kucharczyk M, Konrad C, Schmidt R, Carr R, McMahon S, Schmelz M, Rukwied R.
- Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain.
- Ann Neurol 2018;83:945-957.
- Schuh-Hofer S, Fischer J, Unterberg A, Treede RD, Ahmadi R.
- Spinal cord stimulation modulates descending pain inhibition and temporal summation of pricking pain in patients with neuropathic pain.
- Acta Neurochir 2018; doi: 10.1007/s00701-018-3669-7.
- Cavalli J, Ruttorf M, Rosero Pahi M, Zidda F, Flor H, Nees, F.
- Oxytocin differentially modulates pavlovian cue and context fear acquisition.
- Soc Cogn Affect Neurosci. 2017;12:976-983.
- Sanderson DJ, Lee A, Sprengel R, Seeburg PH, Harrison PJ, Bannerman DM.
- Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia
- Sci Rep 2017;7(1):1765.
- Lischke A*, Herpertz SC*, Berger C, Domes G, Gamer M.
- Divergent effects of oxytocin on (para-) limbic reactivity to emotional and non-emotional scenes in females with and without borderline personality disorder.
- SCAN 2017;12(11):1834,
- Sumser A, Mease RA, Sakmann B, Groh A.
- Organization and somatotopy of corticothalamic projections from L5B in mouse barrel cortex.
- Proc Natl Acad Sci U S A 2017;114(33):8853-88
- Noori HR, Sch�ttler J, Ercsey-Ravasz M, Cosa-Linan A, Varga M, Toroczkai Z, Spanagel R.
- A multiscale cerebral neurochemical connectome of the rat brain.
- PLoS Biol 2017;15(7):e2002612.
- Pallegama RW, Ariyasinghe S, Perera E D, Treede RD
- Influence of Catastrophizing and Personality Traits on Recalled Ratings of Acute Pain Experience in Healthy Young Adults.
- Pain Medicine 2017; 18: 49?60.
- Nees TA, Finnerup NB, Blesch A, Weidner N.
- Neuropathic pain after spinal cord injury: the impact of sensorimotor activity.
- Pain 2017;158(3):371-376.
- Nees F, Becker S, Millenet S, Banaschewski T, Poustka L, Bokde AU, Bromberg U, B�chel C, Conrod PJ, Desrivi�res S, Frouin V, Gallinat J, Garavan H, Heinz A, Ittermann B, Martinot J-L, Papadopoulos-Orfanos D, Paus T, Smolka M, Walter H, Whelan R, Schumann G, Flor H, the IMAGEN consortium.
- Brain substrates of reward processing and the �-opioid receptor: a pathway into pain?
- Pain 2017; 158:212-9.
- Flor H.
- Pain has an element of blank-a biobehavioral approach to chronicity.
- Pain 2017;158:S92-S96.
- Gerhardt A, Eich W, Treede RD, Tesarz J
- Conditioned pain modulation in patients with nonspecific chronic back pain with chronic local pain, chronic widespread pain, and fibromyalgia.
- Pain 2017; 158: 430-439.
- Vollert J, Maier C, Attal N, Bennett DLH, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthm�hlen J, Haanp�� M, Hansson P, H�llemann P, Jensen TS, Magerl W, Ramirez JD, Rice ASC, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, T�lle TR, Treede RD, Baron R
- Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations
- Pain 2017;158:1446-1455.
- Naser PV, Kuner R.
- Molecular, cellular and circuit basis of cholinergic modulation of pain.
- Neuroscience pii: S0306-4522(17)30625-5, 2017
- Nees F, Becker S.
- Psychological processes in chronic pain: influences of reward and fear learning as key mechanisms ?behavioral evidence, neural circuits, and maladaptive changes
- Neuroscience 2017;pii: S0306-4522(17)30627-9.
- Andoh J, Milde C, Tsao JW, Flor H.
- Cortical plasticity as a basis of phantom limb pain: Fact or fiction?
- Neuroscience 2017; S0306-4522(17)30809-6.
- Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA,Lechner SG.
- Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination.
- Neuron2017 Jan 4;93(1):179-193. doi: 10.1016/j.neuron.2016.11.027.
- Godel T, B�umer P, Pham M, K�hn A, Muschol N, Kronlage M, Kollmer J, Heiland S, Bendszus M, Mautner VF.
- Human dorsal-root-ganglion in-vivo morphometry and perfusion in Fabry painful neuropathy.
- Neurology 2017;89:1274-1282.
- Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD.
- Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations.
- Nat Rev Neurol.2017;13(10):624-638
- Artigas F, Schenker E, Celada P, Spedding M, Llado-Pelfort L. Jurado N. Nunez M, Santana N, Troyano-Rodriguez E, Riga MS, van den Munkhof H, Castane A, Shaban H, Jay TM, Tripathi A, Godsil BP, Sebban C, Mariani J, Faure P, Takkilah S, Hughes ZA, Siok CJ, Hajos M, Wicke K, Gass N, Weber-Fahr W, Sartorius A, Becker R, Didriksen M, Bastlund JF, Tricklebank M, Risterucci C, Meyer-Lindenberg A and Schwarz AJ.
- Defining the brain circuits involved in psychiatric disorders: IMINEWMEDS.
- Nat Rev Drug Discov 2017; 16(1): 1-2.
- Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R, Kuner T, Kuner R.
- A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.
- Nat Neurosci 2017;20(11):1591-1601.
- Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski JL, Turnquist B, Bosmans F, Reeh PW, Schmelz M, Carr RW, Ringkamp M.
- Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.
- J NEUROSCI 2017;37(20):5204-5214
- Bas-Orth C, Tan YW, Lau D, Bading H.
- Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.
- J Biol Chem 2017;292(13):5183-5194
- Guo X, Lin Z, Lyu Y, Bekrater-Bodmann R, Flor H, Tong S.
- The Effect of Prosthesis Use on Hand Mental Rotation After Unilateral Upper-Limb Amputation.
- IEEE Trans Neural Syst Rehabil Eng 2017; 25(11):2046-2053.
- Franz S, Schuld C, Wilder-Smith EP, Heutehaus L, Lang S, Gantz S, Schuh-Hofer S, Treede RD, Bryce TN, Wang H, Weidner N.
- Spinal Cord Injury Pain Instrument and painDETECT questionnaire: Convergent construct validity in individuals with spinal cord injury
- Eur J Pain 2017b.
- Kougioumtzidou E, Shimizu T, Hamilton NB, Tohyama K, Sprengel R, Monyer H, Attwell D, Richardson WD.
- Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.
- Elife 2017;6.
- Hidmark A, Spanidis I, Fleming TH, Volk N, Eckstein V, Groener JB, Kopf S, Nawroth PP, Oikonomou D.
- Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes.
- Clinical Therapeutics 2017;39(6):1132-1144.e1132.
- Enger R, Dukefoss DB, Tang W, Pettersen KH, Bjornstad DM, Helm PJ, Jensen V, Sprengel R, Vervaeke K, Otter sen OP, and Nagelhus EA
- Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice.
- Cereb Cortex Cereb Cortex 27, 24-33.
- Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG.
- Functional and Molecular Characterization of Mechanoinsensitive ?Silent? Nociceptors.
- Cell Reports 2017;21:3102?3115.
- Warner FM, Cragg JJ, Jutzeler CR, R�hrich F, Weidner N, Saur M, Maier DD, Schuld C; EMSCI Sites, Curt A, Kramer JK.
- Early Administration of Gabapentinoids Improves Motor Recovery after Human Spinal Cord Injury.
- Cell Reports 2017;18(7):1614-1618.
- Melzer S, Gil M, Koser DE, Michael M, Huang KW, Monyer H.
- Distinct corticostriatal GABAergic neurons modulate striatal output neurons and motor activity.
- Cell Reports 2017;19(5):1045-1055.
- Mease RA, Kuner T, Fairhall AL, Groh A.
- Multiplexed Spike Coding and Adaptation in the Thalamus.
- Cell reports 2017;19(6):1130-1140.
- Andoh J, Diers M, Milde C, K�ppe C, Kleinb�hl D, Flor H.
- Neural correlates of evoked phantom limb sensations.
- Biological Psychology 2017; 126:89-97.
- Reinwald JR, Becker R, Mallien AS, Falfan-Melgoza C, Sack M, Clemm von Hohenberg C, Braun U, Cosa Linan A, Gass N, Vasilescu AN, Tollens F, Lebhardt P, Pfeiffer N, Inta D, Meyer-Lindenberg A, Gass P, Sartorius A, Weber-Fahr W.
- Biol Psychiatry, 2017; S0006-3223(17)32317-X. doi: 10.1016/j.biopsych.2017.12.010.
- Jende JME, Hauck GH, Diem R, Weiler M, Heiland S, Wildemann B, Korporal-Kuhnke M, Wick W, Hayes JM, Pfaff J, Pham M, Bendszus M, Kollmer J.
- Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography.
- Annals of Neurology 2017;82(5):676-685.
- Song K, Wang H, Kamm GB, Pohle J, Reis FC, Heppenstall P, Wende H, Siemens J.
- The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.
- Science 2016;353(6306):1393-1398.
- Braun U, Sch�fer A, Bassett DS, Rausch F, Schweiger J, Bilek E, Erk s, Romanczuk-Seiferth N, Grimm O, Geiger L, Haddad L, Otto K, Mohnke S, Heinz A, Zink M, Walter H, Schwarz E, Meyer-Lindenberg A, Tost H.
- Dynamic reconfiguration of brain networks: a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function
- Proc Natl Acad Sci USA 2016;113(44):12568-73.
- Pitzer C, Kuner R, Tappe-Theodor A.
- Voluntary and evoked behavioural correlates in inflammatory pain conditions under different social housing conditions.
- Pain Reports 2016;1:e564.
- Nees TA, Tappe-Theodor A, Sliwinski C, Motsch M, Rupp R, Kuner R, Weidner N, Blesch A.
- Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury.
- Pain 2016;157(3):687-697.
- Tesarz J, Eich W, Treede RD, Gerhardt A.
- Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment: a quantitative sensory testing study.
- Pain 2016;157(8):1799-809.
- Mease RA, Sumser A, Sakmann B, Groh A.
- Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo.
- Cereb Cortex 2016;26(8):3461-3475.
- Mease RA, Sumser A, Sakmann B, Groh A.
- Cortical Dependence of Whisker Responses in Posterior Medial Thalamus In Vivo.
- Cereb Cortex 2016;26(8):3534-3543.
- Mease RA, Metz M, Groh A.
- Cortical Sensory Responses Are Enhanced by the Higher-Order Thalamus.
- Cell reports 2016;14(2):208-215.
- Shabes P, Schloss N, Magerl W, Schmahl C, Treede RD, Baumg�rtner U
- A novel human surrogate model of noninjurious sharp mechanical pain.
- Pain 157(1):214-24.
- Nees TA, Tappe-Theodor A, Sliwinski C, Motsch M, Rupp R, Kuner R, Weidner N, Blesch A.
- Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury.
- Pain 2016;157:687-697.
- Cragg JJ, Haefeli J, Jutzeler CR, Rohrich F, Weidner N, Saur M, Maier DD, Kalke YB, Schuld C, Curt A, and Kramer JK.
- Effects of Pain and Pain Management on Motor Recovery of Spinal Cord-Injured Patients: A Longitudinal Study.
- Neurorehab and Neural Repair 2016; 30(8):753-61.
- Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F
- The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.
- Neuron 2016;92(2):419-434.
- Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Busnelli M, Chini B, Tan L, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.
- A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.
- Neuron2016 89(6): p. 1291-1304
- Fuchs EC, Neitz A, Pinna R, Melzer S, Caputi A, Monyer H.
- Local and distant input controlling excitation in layer II of the medial entorhinal cortex.
- Neuron 2016;89(1):194-208.
- Godel T, Pham M, Heiland S, Bendszus M, B�umer P.
- Human dorsal-root-ganglion perfusion measured in-vivo by MRI.
- Neuroimage. 2016;141:81-87.
- Kuner R and Flor H,
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- Nature Reviews Neuroscience, 18(1):20-30, 2016
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